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KMID : 0604520050310020147
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Journal of the Society of Cosmetic Scientists of Korea
2005 Volume.31 No. 2 p.147 ~ p.152
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Screening of Traditional Herbal Medicines to Develop New Materials for Anti-aging and Anti-wrinkle in the Skin
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Lee Sang-Eun
Yoon Yeo-Pil
Lim Tae-Hyung
Cho Ja-Woon
Kim Hyun-Su
Son Dong-Wook
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Abstract
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As a part of searching tot the natural components which inhibit the skin aging and wrinkle formation, the 80% methanolie extracts of 121 species of traditional herbal medicines used to treat lung and skin disease were investigated for their in vitro anti-oxidative activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) and superoxide radicals, and inhibitory activity against elastase. We selected 9 kinds of the traditional herbal medicines showing inhibitory activities of winkle formation. The effective concentrations of 9 candidates for anti-wrinke/skin firming activity was less than 0.1 mg/mL, and there is no toxicity to cell viability at these concentrations. Through analysis of human skin primary patch test data, the traditional herbal medicines represented non-irritant materials. We suggest that these 9 candidates with ability to help anti-wrinkle/skin firming may be useful for functional cosmetic materials.
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KEYWORD
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anti-wrinke/anti-aging elastase inhibitory activity, traditional herbal medicines, anti-oxidative activity
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